Glucophage. Pharmacological Action
Glucophage is oral antihyperglycemic medication. The main constituent of Glucophage is metformin. This substance possesses expressed hypoglycemic action which develops in case only of hyperglycemia. At patients with normal glucose level this preparation doesn’t perform hypoglycemic action. This preparation decreases the glucose level in blood and also while taking meal. The mechanism of this preparation’s actions is able to depress gluconeogenesis and glycogenolysis increasing in such a way insulin sensitivity and also decreases glucose absorption in the digestive tract. Metformin reduces the level of triacylglycerol, cholesterol and low-density lipoprotein. Glucophage may be ordered via Canadian Neighbor Pharmacy at more favourable term in comparison with usual drug stores.
The preparation is applied as therapy of the patients suffering from diabetes of the II type at which the dietotherapy doesn’t give necessary effect. The preparation is appointed as monotherapy, and also in a complex with other oral hypoglycemic means or insulin. The preparation of Glucophage can be appointed to children aged is senior than 10 years as monotherapy or in a complex with other oral hypoglycemic means or insulin.
Glucophage is a preparation effective in diabetes treatment. It may be ordered via Canadian Neighbor Pharmacy. You may surf our website to know more about us and the procedure of making orders.
The increased individual sensitivity to preparation components. The preparation isn’t applied as therapy of patients with diabetic precoma, coma, and also diabetic ketoacidosis. The preparation isn’t appointed to the patients suffering from kidneys dysfunction with clearance of creatinine less 60ml/min, serious conditions which can be followed by kidneys dysfunction, including dehydration, heavy forms of infectious diseases and shock.
The preparation isn’t taken during diagnostic procedures which demand application of iodinated X-ray contrast means (reception of preparation should be stopped not less than in 48 hours prior to introduction of iodinated X-ray contrast means). The preparation is contraindicated to the patients having acute and chronic diseases which can be followed by hypoxia, including acute myocardial infarction, shock expressed by respiratory or heart failure. The preparation isn’t used before carrying out surgeries (intake of preparation should be stopped not less than in 48 hours prior to surgery), and also for treatment of patients with liver dysfunction, heavy ethanol intoxication and alcoholism.
Intake during Pregnancy
Preparation’s application during pregnancy is contraindicated. Women of childbearing age before purpose of Glucophage should exclude pregnancy. During therapy by a preparation of the woman of childbearing age have to use well-tried remedies of contraception. In case of planning or approach of pregnancy reception of preparation should be cancelled. In need of preparation’s application in the period of lactation it is necessary to consult with the attending physician and to resolve an issue of breastfeeding interruption.